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Bernard Ducommun Selected Research

cdc25 Phosphatases

4/2009Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors.
3/2009IRC-083864, a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells.
10/2008Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
7/2007CDC25 phosphatases in cancer cells: key players? Good targets?
9/2005Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.
1/2003Inhibitors of the CDC25 phosphatases.

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Bernard Ducommun Research Topics

Disease

25Neoplasms (Cancer)
11/2021 - 01/2003
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
03/2012 - 07/2006
2Hypoxia (Hypoxemia)
02/2018 - 01/2016
1Adenocarcinoma
12/2016
1Starvation
02/2013
1Chromosomal Instability (Chromosome Stability)
01/2013
1Genomic Instability
03/2012
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2012
1Ataxia Telangiectasia (Louis Bar Syndrome)
06/2009
1Type II Microcephalic Osteodysplastic Primordial Dwarfism
06/2009
1Microcephaly
06/2009
1Carcinoma (Carcinomatosis)
07/2008
1Colonic Neoplasms (Colon Cancer)
01/2007
1Alzheimer Disease (Alzheimer's Disease)
01/2003

Drug/Important Bio-Agent (IBA)

6cdc25 PhosphatasesIBA
04/2009 - 01/2003
3Paclitaxel (Taxol)FDA LinkGeneric
01/2021 - 01/2007
2Oxygen (Dioxygen)IBA
02/2018 - 01/2016
2Etoposide (VP 16)FDA LinkGeneric
02/2018 - 02/2013
2BN 82685IBA
01/2007 - 09/2005
1Histone Deacetylase InhibitorsIBA
11/2021
1Vinorelbine (Navelbine)FDA LinkGeneric
01/2021
1NocodazoleIBA
01/2019
1fluorexon (calcein)IBA
01/2018
1Hyaluronic Acid (Hyaluronan)IBA
12/2016
1Nonmuscle Myosin Type IIAIBA
06/2015
1Lovastatin (Mevacor)FDA LinkGeneric
02/2013
1Epidermal Growth Factor (EGF)IBA
02/2013
1Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric
01/2013
1Centrosomal Associated ProteinsIBA
01/2013
1Ethanol (Ethyl Alcohol)IBA
03/2012
1Phosphotransferases (Kinase)IBA
03/2012
13- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA
03/2012
1GemcitabineFDA Link
01/2012
1Drug CombinationsIBA
01/2012
1Histones (Histone)IBA
12/2011
1Proteins (Proteins, Gene)FDA Link
12/2011
1Antimitotic AgentsIBA
12/2011
1pericentrinIBA
06/2009
1Aurora KinasesIBA
06/2009
1Antineoplastic Agents (Antineoplastics)IBA
04/2009
12- (2,5- difluorophenyl)- 6- ((3- (methyl(3- ((2- methyl- 4,7- dioxo- 4,7- dihydro- 1,3- benzothiazol- 5- yl)amino)propyl)amino)propyl)amino)- 1,3- benzoxazole- 4,7- dioneIBA
03/2009
1quinone (benzoquinone)IBA
03/2009
1Fibronectins (Fibronectin)IBA
07/2006
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
06/2006
1EnzymesIBA
09/2005
1Dual-Specificity PhosphatasesIBA
08/2005
1Protein Isoforms (Isoforms)IBA
08/2005
1BN82002IBA
05/2004

Therapy/Procedure

8Therapeutics
03/2012 - 04/2006